Voluntary exercise reduces both chemotherapy-induced neuropathic nociception and deficits in hippocampal cellular proliferation in a mouse model of paclitaxel-induced peripheral neuropathy.

Voluntary exercise increased the number of BrdU-expressing cells irrespective of chemotherapy status [and the interaction between chemotherapy treatment and exercise condition approached significance ( Fig. 1 F). 3.3 Study 2: cessation of exercise prior to CIPN: prior running wheel activity partially delays the onset of paclitaxel-induced allodynia Running wheel activity did not differ between groups prior to the initiation of paclitaxel or vehicle treatment.

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