31 Likewise, here the presence or absence of variant repeats ( figure 2C ) was revealed as a highly significant ( p = 4.9 × 10 −8 ) additional measure in the regression model ( table 2 , model 2b, r 2 = 0.610, p < 2.2 × 10 −16 ).
40 Here, sex was revealed as having a marginally significant effect ( p = 0.015) on age at onset ( table 1 , model 1c, r 2 = 0.257, p = 1.2 × 10 −14 ).
40 In the OPTIMISTIC cohort, incorporating the standardized residuals of somatic instability derived from model 2b into the age at onset model ( table 1 , model 1d, r 2 = 0.260, p = 3.0 × 10 −14 ) improved the r 2 value slightly from model 1c, but the standardized residuals of somatic instability did not reach statistical significance as a measure ( p = 0.19).