Expression of the RIG-I like helicases RIG-I and MDA5 showed a trend towards lower expression after rhinovirus infection in murine macrophages stimulated with GM-CSF compared to those stimulated with M-CSF (Fig. 2A, B ) as confirmed on protein level (Fig. 2D ).
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Rhinovirus-induced IFNβ expression is NFκB-dependent and regulated by the macrophage microenvironment.
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