Frequency of Appropriate Use of Pancreatic Enzyme Replacement Therapy and Symptomatic Response in Pancreatic Cancer Patients.

A more recent randomized study showed an increase in overall survival in patients randomized to taking PERT but did not reach statistical significance due to a low enrollment rate, with only 18 patients randomized prior to closure of the study. 23 A prospective cohort study of unresectable PC patients receiving chemotherapy showed improved changes in body mass index and increased overall survival of patients who received PERT retrospectively compared with prior patients receiving chemotherapy as historical controls. 24 These clinical trials investigating PERT used various doses, ranging from 40,000 to 72,000 units of lipase for meals and 20,000 to 36,000 units of lipase per snack.

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