The Oxysterol Synthesising Enzyme CH25H Contributes to the Development of Intestinal Fibrosis.

J Crohns Colitis · 2019 · PMC6751338 · PMID 31220227

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Additionally, mRNA expression levels for fibrosis markers such as Tgf-β , collagen type 3 [ Col-3 ] and Timp-1 were significantly lower in the colon of Ch25h -/- animals, and a clear trend for lower mRNA expression of collagen type 1 [Col-1 ] and lysyl oxidase homologue 2 [ Loxl-2 ] in CH25H-deficient mice was found [ Figure 2E –J ].

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