Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia.

Examination of individual myofibers from tissues with maintained muscle mass showed a trend toward increased cross-sectional area; the very small atrophic fibers that are found with age were in particular absent with low-dose rapalog treatment.

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For the most part, the expression levels of these genes remained unchanged in gastrocnemius and plantaris muscles following RAD001 treatment, although we observed a trend toward significance in reduction of Chrnε mRNA levels with LD RAD001 in the plantaris ( Fig. 5B and C ).

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