The effect of NOTCH3 pathogenic variant position on CADASIL disease severity: NOTCH3 EGFr 1-6 pathogenic variant are associated with a more severe phenotype and lower survival compared with EGFr 7-34 pathogenic variant.

Genet Med · 2019 · PMC6752295 · PMID 30032161

Europe PMC DOI

hedged sentence

0.1320

closest p · 2.6× alpha

0.1320

boldest claim

The sentences

did not reach statistical significanceP = 0.132not close (p > 0.1)

There was a small difference in the age-dependent increase in nWMHV for individuals with an EGFr 1–6 PV versus individuals with an EGFr 7–34 PV, but this difference did not reach statistical significance ( P = 0.132).

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