IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM.

2d ), only Prevotella copri and Eubacterium biforme showed a trend towards higher coating with sIgM in the sIgAd subjects than sIgA in the healthy control cohort, but neither difference was significant after correction with Dunn’s multiple comparisons (Supplemental Fig. 11 ).

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Notably, we observed the strongest trends towards decreased alpha diversity in sIgAd subjects when evaluating diversity using OTUs or Chao1 and only observed a weak trend for the Shannon diversity index, while Jorgensen et al . observed a significant reduction in alpha diversity for all metrics including the Shannon diversity index.

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