Early onset of efficacy with erenumab in patients with episodic and chronic migraine.

In the EM study, erenumab treatment was associated with nominally significant reductions in WMD compared to placebo as early as Week 1 and for all doses by Week 4; (LSM change from baseline [95% CI]) in the EM study: placebo (− 0.1 [− 0.3, 0.0]), 70 mg (− 0.3 [− 0.5, − 0.2]; p = 0.130) and 140 mg (− 0.6[− 0.7, − 0.4]; p < 0.001) for Week 1; placebo (− 0.4 [− 0.5, − 0.2]), 70 mg (− 0.6 [− 0.8, − 0.5]; p = 0.029) and 140 mg (− 0.6 [− 0.8, − 0.5]; p = 0.019) at Week 4.

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