TMED9 quintiles showed a trend where top expressors showed poorer outcomes, but these did not reach significance of p = 0.05 (Supplemental Fig. 13 ), much as reported for TMED3 [ 8 ].
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The protein secretion modulator TMED9 drives CNIH4/TGFα/GLI signaling opposing TMED3-WNT-TCF to promote colon cancer metastases.
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