Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia.

Patient-derived OPCs exhibited a size distribution that was strongly shifted toward smaller cells, a finding that was highly significant across all patient and control lines (Kolmogorov–Smirnov D = 0.25, P = 3.0 × 10 −8 ; Fig. 3d ).

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The second mutation ( CSPG4 V901G ), also located in a LamG domain, segregated with schizophrenia in two independent pedigrees and exhibited nominally significant enrichment in the Swedish Schizophrenia Exome Sequencing Study [ 8 ].

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