Optimizing Mycophenolic Acid Exposure in Kidney Transplant Recipients: Time for Target Concentration Intervention.

34 By logistic regression analysis, the relationship between randomly assigned MPA AUCt 0-12 and rejection was highly significant ( P < 0.001). 26 Increasing MPA AUCt 0-12 was associated with a reduction in the probability of BPAR by 50%, 75%, and 90% at MPA AUCt 0-12 values of 15, 25, and 40 mg/L.h, respectively. 26 The association between rejection and trough MPA total concentration was also significant, though weaker ( P < 0.01).

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26 , 31 , 35 , 41 , 74 , 77 - 79 , 81 , 83 - 87 , 89 , 91 - 93 , 95 - 98 An additional 3 studies showed a trend in favor of this association (5.7% of individuals), 80 , 90 , 94 leaving only 4 cohorts (5.1% of individuals) without association. 75 , 76 , 82 For cyclosporine cotreated transplant recipients, 12 of 16 cohorts (comprising 1181 of 1518 individuals, 77.8%) reported a statistically significant associ

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