Low expression of RNA sensors impacts Zika virus infection in the lower female reproductive tract.

However, absence of Mavs together with either Tlr3 ( Mavs −/− Tlr3 −/− ) or Tlr7 ( Mavs −/− Tlr7 −/− ) resulted in moderately enhanced ZIKV copy numbers in the LFRT, although the difference in viral copies between WT and Mavs −/− Tlr7 −/− mice did not reach statistical significance (Fig. 3a ).

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