MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition.

Although there was a trend towards increased serum levels of IL-1β, the low measured concentrations did not reach statistical significance compared to tamoxifen-treated Nlrp3 A350V/+ CreT − littermate mice ( S1D Fig and S7 Data ).

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