Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain.

The association between MRS and ΔBMI in non-smoking samples is highly significant (n = 1,243, β = 0.045, p = 1.96 x 10 −7 , R 2 = 0.021), albeit with a slightly diminished effect size estimate (empirical p < 0.0061, calculated using 10,000 random samplings of 1,243 FHS samples) compared to association in all samples (n = 1,508, β = 0.055, p = 5.80 x 10 −12 , R 2 = 0.031).

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In conditional analyses, the relationship between ΔBMI and MRS remained nominally significant after adjusting for each of the glycemic variables ( Fig 2A and S3 Table ), implying that the MRS is not solely a proxy for insulin sensitivity.

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