Calcitriol Analogues Decrease Lung Metastasis but Impair Bone Metabolism in Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Tumours.

PRI-2205 significantly decreased the plasma level of OPN on days 14 and 28, and a similar trend was noted for PRI-2191, although it did not reach statistical significance ( Fig. 4E ).

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