KRAS, NRAS, BRAF, HER2 and microsatellite instability in metastatic colorectal cancer - practical implications for the clinician.

Radiol Oncol · 2019 · PMC6765160 · PMID 31553708

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did not reach statistical significanceno p-value reported

The results of these retrospective studies did not reach statistical significance and were insufficient for a definitive conclusion about the potential use of BRAF V600E as a biomarker for determining primary resistance to anti-EGFR agents in CRC. 61 , 62 , 63 , 64 , 65 Therefore, the predictive role of the BRAF mutation for anti-EGFR agents after two meta-analyses is still uncl

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