Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis.

FASEB J · 2019 · PMC6766660 · PMID 31291762

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did not reach statistical significanceP < 0.001actually significant

Concentrations of NT-3 also exhibit elevated levels in EAMs but this data did not reach statistical significance ( Fig. 4 C ). mRNA concentrations of IGF-1 were significantly elevated in EAMs ( P < 0.001) compared with all other macrophages, including macrophages activated with PF from women without endometriosis [M(No Endo); P < 0.05, Fig. 4 D )].

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