Syndrome of inappropriate anti-diuretic hormone secretion in cancer patients: results of the first multicenter Italian study.

Stratified by gender, median OS was 11 months in males and 24 months in females ( p = 0.0016). Regarding stage at diagnosis, median OS was significantly lower in metastatic patients (11 versus 30 months, p = 0.0181). Therefore, univariate analysis demonstrated that with the lung as the primary site, male gender and tumor stage IV at diagnosis were significantly associated with worse OS, while comorbidities ( p = 0.4643), liver ( p = 0.5698), lung ( p = 0.1209), or bone ( p = 0.1891) metastases, and number of treatment lines before hyponatremia ( p = 0.0808) did not reach statistical significance.

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