Lower Relative Contribution of Positive Family History to Colorectal Cancer Risk with Increasing Age: A Systematic Review and Meta-Analysis of 9.28 Million Individuals.

Individuals with ≥2 FDRs affected had higher risk of CRC than those with one FDR affected (RR = 2.68, 95% CI = 1.92‐3.74, I 2 = 75.0% versus RR = 1.82, 95% CI = 1.51‐2.18, I 2 = 76.3%), but the difference did not reach statistical significance as demonstrated by an overlap of their 95% CIs.

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