Endogenous Neuropeptide Nocistatin Is a Direct Agonist of Acid-Sensing Ion Channels (ASIC1, ASIC2 and ASIC3).

The identical efficiency with which the toxin Mamb-2 inhibits the nocistatin- and proton-induced activation of ASIC1a ( Figure 2 f), as well as the similarity of the curves of nocistatin- and proton-dependent activation of the channel [ 34 ], indicate a similarity of the mechanisms of these activations, although there are quite significant differences in desensitization rates.

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