Expression of FGFR1-4 in Malignant Pleural Mesothelioma Tissue and Corresponding Cell Lines and its Relationship to Patient Survival and FGFR Inhibitor Sensitivity.

FGFR4 expression, was detectable only in 6 of 81 patients (7.4%) and showed a highly significant correlation with a shorter OS (P = 0.0027). 3.3.

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Despite the absence of significant correlations between staining pattern and histology for any of the FGFRs, an overall trend towards low or absent staining was observed for sarcomatoid tumors ( Figure 2 A, Tables S1–S3 ).

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While the correlation between high FGFR4 mRNA and BLU9931 sensitivity did not reach statistical significance, notably, the two cell lines with the highest FGFR4 mRNA showed the highest sensitivity towards the FGFR4 inhibitor ( Figure 4 D). 4.

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