Global Proteome of <i>LonP1</i>^+/- Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes.

However, the effects were clearly non-random, with highly significant enrichments of specific pathways and an overall protein–protein-interaction enrichment p -value of <1.0 × 10 −16 upon bioinformatics analysis at the STRING (search tool for the retrieval of interacting genes) webpage in Heidelberg.

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Bioinformatic Analyses For protein–protein-interaction (PPI) network analysis, the software tool STRING (Search tool for the retrieval of interacting genes) v.11.0 ( https://string-db.org/ ) with standard settings was used to visualize networks among factors with nominally significant difference between HET and WT status, using three biological replicates [ 93 ].

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