Barely Significant
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Gray matter T1-w/T2-w ratios are higher in Alzheimer's disease.

Hum Brain Mapp · 2019 · PMC6771703 · PMID 31157938

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showed a trendno p-value reported
However uncorrected results showed a trend of higher T1‐w image intensity in AD patients in the inferior parietal lobule, angular gyrus, precuneus, and superior parietal lobule.

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highly significantno p-value reported
Moreover, the differences in T1‐w/T2‐w ratio between AD and NC individuals are highly significant, however the effect sizes are too small to be of clinical significance.

also in 132,142 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.