Randomized, Double-Blind, Placebo-Controlled Trial of Intraarticular Trans-Capsaicin for Pain Associated With Osteoarthritis of the Knee.

At week 12, the time of the designated primary end point, divergence from placebo was highly significant ( P < 0.001) with the 1 mg dose.

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Improvements at weeks 4, 8, 12, and 16 in patients receiving the 1.0 mg dose were statistically significant at the prespecified alpha level of ≤0.1 versus placebo; improvements at 24 weeks did not reach statistical significance (Supplementary Table 2 , http://onlinelibrary.wiley.com/doi/10.1002/art.40894/abstract ).

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