The polymorphism in HTR3E c.*76G > A rs561098476 showed a trend towards association with more responders carrying the GG genotype compared to nonresponders, although this was nonsignificant ( P = .09, see supplementary data).
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Abnormalities of mucosal serotonin metabolism and 5-HT<sub>3</sub> receptor subunit 3C polymorphism in irritable bowel syndrome with diarrhoea predict responsiveness to ondansetron.
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