Effect of Low-Dose Aspirin on Soluble FMS-Like Tyrosine Kinase 1/Placental Growth Factor (sFlt-1/PlGF Ratio) in Pregnancies at High Risk for the Development of Preeclampsia.

The sFlt-1/PlGF ratio was significantly higher in women with an adverse obstetric outcome compared to women with a normal pregnancy in high- and low-risk pregnancies and showed an increasing trend throughout gestation Several studies already reported altered maternal concentrations of sFlt-1 and PlGF before and at the onset of preeclampsia [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 ] and therefore have a high predictive value [ 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ].

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The use of aspirin showed a trend towards an improvement of the sFlt-1/PlGF ratio in women with preeclampsia in a previous pregnancy and a significant effect on the sFlt-1/PlGF ratio in women with a pathologic first trimester screening for preeclampsia.

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