CD97 is a critical regulator of acute myeloid leukemia stem cell function.

Consistent with reduced levels of leukemic engraftment from CD97 −/− -MA9 transduced HSPCs, at the experimental endpoint, the mice injected with WT-MA9 cells showed a trend toward containing a higher percentage of total GFP + cells, leukemic granulocyte-monocyte progenitors (L-GMPs; Lin − Sca-1 + c-Kit + F c γR + CD34 + ; Krivtsov et al., 2006 ; Fig. 2 D ), and CD11b + Gr1 + cells in the BM (Fig.

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