International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci.

Nat Commun · 2019 · PMC6783435 · PMID 31594949

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0.0520

closest p · 1.0× alpha

0.0520

boldest claim

The sentences

marginally significantP = 0.052so close (0.05 < p ≤ 0.1)

Next, focusing on PGC1.5 women only, a comparison to UKB showed significant genetic correlations with the overall UKB ( r g = 0.46, P = 0.0004) and UKB women ( r g = 0.46, P = 0.0008), and a slightly lower, but marginally significant correlation with the smaller UKB male data ( r g = 0.44, P = 0.052).

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nominally significantno p-value reported

Heterogeneity between datasets was tested with a Cochran test and for nominally significant Q-values, a Han-Eskin random effects model (RE-HE) meta-analysis was performed with METASOFT v.2.0.1 77 .

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highly significantno p-value reported

In addition, we construct a highly significant polygenic risk score for PTSD, which is predictive of re-experiencing symptoms (REX), a core feature of PTSD, in the independent Million Veteran Program cohort 9 .

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