Severe Cardiac Dysfunction and Death Caused by Arrhythmogenic Right Ventricular Cardiomyopathy Type 5 Are Improved by Inhibition of Glycogen Synthase Kinase-3β.

At 2 months of age, TMEM43mut mice showed increased levels of cleaved caspase 3, which were maintained at 4 months, although the differences did not reach statistical significance (Figure 3 B and Figure IIIA in the online-only Data Supplement ).

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