Bisphenols showed a trend of LINE-1 hypomethylation that was ER-dependent with BPA and BPF We tested the effects of functional (equipotent) doses of BPA and its analogs on LINE-1 methylation, which additionally served as a screening tool to determine the earliest time points and concentrations at which overall methylation alterations occur, so that these conditions can be subsequently analyzed in-depth with genome-wide methylation profiling.
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DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer.
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