Limited synergy of obesity and hypertension, prevalent risk factors in onset and progression of heart failure with preserved ejection fraction.

Histological analysis of activated Caspase 3, a marker of early apoptosis, indicated no significant changes in sub‐endocardial apoptosis (Figure S2 A and C), although the apoptotic effect of DS‐induced hypertension showed a trend ( P = .05; Table S9 ).

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