Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.

A small decrease in BrdU incorporation was observed in Nr2f6 -deficient Tfh cells and GC B cells, but not in PCs; these changes did not reach statistical significance ( Figure S2 B).

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Interaction-plot analysis of CD4 T cells under resting versus Tfh cell stimulation conditions revealed a highly significant reduction in NR2F6 binding to the Il21 promoter and the CNS −36 regions following stimulation, and within each region, regression curves of log-transformed data are shown ( Figures S6 F–S6H).

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