Barely Significant
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The TLR7/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer.

Nat Commun · 2019 · PMC6794326 · PMID 31615993

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Both total macrophages (CD45 + F4/80 + ) and CD11c − macrophages trended toward increases with R848, but did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.