Removal of the Potassium Chloride Co-Transporter from the Somatodendritic Membrane of Axotomized Motoneurons Is Independent of BDNF/TrkB Signaling But Is Controlled by Neuromuscular Innervation.

eNeuro · 2019 · PMC6795555 · PMID 31541001

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showed a trendno p-value reported

Because KCC2 mRNA was depleted by 3 d after injury, and our time course of KCC2 protein depletion showed a trend toward KCC2 loss on the soma at this time point, we further investigated this time point by examining KCC2 distribution on AAV1-mCherry labeled motoneuron somata and dendrites of animals 3 d after sciatic nerve cut and ligation.

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highly significantno p-value reported

Paired t tests showed highly significant reductions in kcc2 mRNA signal in both cytoplasm and nucleus.

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