Genetic variants of chromosome 9p21.3 region associated with coronary artery disease and premature coronary artery disease in an Asian Indian population.

The CC genotype of rs1333049 (G/C), a highly replicated SNP, showed a trend toward risk association with premature CAD in the study population ( P = 0.061 in the recessive model). 41 , 42 Further, we found that the AA genotype of rs16905599 (G/A) is associated with more than 2.4-fold risk for CAD in the study population ( P = 0.025 in the codominant model and P = 0.0069 in the recessive model).

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