A comprehensive study of metabolite genetics reveals strong pleiotropy and heterogeneity across time and context.

Interestingly, that variant, which was only border-line nominally significant in the standard marginal model ( P = 0.058), was reported to be associated with HDL, LDL, TG, and TC ( P = 7.9 × 10 −20 , P = 1.1 × 10 −34 , P = 3.5 × 10 −28 , P = 2.5 × 10 −32 , respectively) in the Willer et al. 28 study that included 188,577 individuals (Supplementary Data 5 ).

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