Characteristics of familial type 1 diabetes: effects of the relationship to the affected family member on phenotype and genotype at diagnosis.

Autoantibodies When adjusted for age and sex, autoantibody negativity was more frequent among children with familial vs sporadic disease (Table 1 ), and a similar difference was seen especially among those with more than one affected FDR compared with those with sporadic disease, although it did not reach statistical significance after adjustment ( p = 0.091) (Table 3 ).

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