DSS-induced colitis produces inflammation-induced bone loss while irisin treatment mitigates the inflammatory state in both gut and bone.

Sci Rep · 2019 · PMC6805923 · PMID 31641205

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did not reach statistical significanceno p-value reported

Cancellous bone volume, while not different between DSS and DSS + Ir groups at the proximal tibia, was slightly higher at the 4 th lumbar vertebra (+22%) and femoral neck (+24%) compared to untreated DSS animals, although this did not reach statistical significance.

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