A placebo-controlled trial of folic acid and betaine in identical twins with Angelman syndrome.

Orphanet J Rare Dis · 2019 · PMC6806546 · PMID 31640736

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showed a trendno p-value reported

Previous studies have shown that patients with Class I deletion are at higher risk of autism than others with Angelman syndrome, and those subjects in the trial without autism showed a trend toward a beneficial effect of the treatment [ 7 ].

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