No significant difference in colonic IL-10 or IL-6 was detected between DSS and DSS + MetT treated mice, suggesting that MetT exhibited no immunomodulatory effects during DSS-induced colitis; although, there was a weak trend to decreased IL-6 in DSS + MetT, compared to DSS treated mice ( Fig. 8 b).
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The nitroxide 4-methoxy-tempo inhibits the pathogenesis of dextran sodium sulfate-stimulated experimental colitis.
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Similar to our previous investigation [ 14 ], DSS-induced colitis resulted in significant monocyte and neutrophil recruitment to the inflamed colon tissue, while macrophages showed a trend to increase in the colon, when compared to mice in the absence of DSS (see panels Fig. 5 m, n and o, respectively).