Christmas disease in a Hovawart family resembling human hemophilia B Leyden is caused by a single nucleotide deletion in a highly conserved transcription factor binding site of the <i>F9</i> gene promoter.

Haematologica · 2019 · PMC6821609 · PMID 30846504

Europe PMC DOI

hedged sentences

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP =2.2×10 −6actually significant

As shown in Figure 3 the mutated promoter fragment resulted in a statistically highly significant ( P =2.2×10 −6 ) reduction of the relative response ratio to approximately 34.6% of the wildtype promoter in the presence of C/EBP (+ C/EBP).

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weakly significantP <0.01actually significant

Values were considered statistically significant when P <0.05 (weakly significant), P <0.01 (medium-strength significance) and P <0.001 (strongly significant).

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