In Supplemental Figure 3 subjects were grouped according to their sex and BMI and as observed for the in vitro Treg induction depicted in Supplemental Figure 2 , the positive effect of cold showed a trend towards increased ex vivo Treg frequencies in all sub-groups and was more pronounced in the obese sub-cohort (FOXP3 high CD25 high CD127 low [% of CD3 + CD4 + ] of T 0 vs.
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