Developmental conditions modulate DNA methylation at the glucocorticoid receptor gene with cascading effects on expression and corticosterone levels in zebra finches.

Furthermore, the correlations approached significance for lower receptor expression being associated with lower CORT increase in response to restraint (r = 0.50; F 1,13 = 4.23; p = 0.06; Fig. 5c ) and higher CORT after dexamethasone injection (r = −0.49; F 1,13 = 4.23; p = 0.06; Fig. 5e ), whereas we found no significant association between receptor expression and stress-induced CORT (r = −0.28; F 1,13 = 1.10; p = 0.31; Fig. 5b ), negative feedback (r = −0.38; F 1,13 = 2.27; p = 0.15; Fig. 5d ), and CORT after ACTH (r = 0.07; F 1,13 = 0.06; p = 0.81; Fig. 5g ).

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