TCF7L2 polymorphisms are associated with amygdalar volume in elderly individuals with Type 2 Diabetes.

In the joint analysis of rs11196205 and each of the other three SNP (separately), the association with amygdalar volume was still significant (regression model A- p = 0.039, p = 0.044, p = 0.033 – controlling for rs7901695, rs7903146 or rs12255372 respectively), or approaching significance (model B- p = 0.08, p = 0.086, p = 0.067 – controlling for rs7901695, rs7903146 or rs12255372 respectively) (Table 7 ).

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Therefore, we assume that none of the three SNPs rs7901695, rs7903146 and rs12255372 contributed independently to the association with amygdalar volume, beyond the effect of the most highly significant SNP rs11196205.

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