Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model.

On the other hand, there appeared to be an overall trend of increased T cell frequency ( Fig. 8 H ) upon PLX3397 treatment.

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S5) revealed that PLX3397 treatment reduced or showed a trend of reducing the frequency of dendritic cells (DCs), natural killer (NK) cells, and Ly6C − monocytes in all groups of mice ( Fig. 8, D–F ).

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While there was a slight trend, PLX3397-treated TEKO mice did not show a significantly increased brain volume compared with control TEKO mice ( Fig. 1 ).

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