Barely Significant
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Prime-pull vaccination with a plant-derived virus-like particle influenza vaccine elicits a broad immune response and protects aged mice from death and frailty after challenge.

Immun Ageing · 2019 · PMC6829930 · PMID 31700523

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Again, the IIV-IM/IM group mounted little-to-no CD8 + T cell response above baseline levels except for IL-2 production (0.03% versus 0.001% in the PBS group) although this difference did not reach statistical significance.

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