20(<i>S</i>)-Protopanaxadiol Saponins Mainly Contribute to the Anti-Atherogenic Effects of <i>Panax notoginseng</i> in ApoE Deficient Mice.

As shown in Figure 8 A, the mRNA expressions of IL-6, MCP-1, and nuclear factor kappa B (NF-κB) was greatly up-regulated in the aorta from un-treated ApoE −/− mice compared with CON mice, and the increased expressions of all these genes tested were inhibited by the treatment of PNS, PTS, or PDS, although the changes in NF-κB expression did not reach statistical significance between the MOD and PDS groups.

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