Inducible Cardiac-Specific Deletion of Sirt1 in Male Mice Reveals Progressive Cardiac Dysfunction and Sensitization of the Heart to Pressure Overload.

Int J Mol Sci · 2019 · PMC6834316 · PMID 31658614

Europe PMC DOI

hedged sentence

0.0550

closest p · 1.1× alpha

0.0550

boldest claim

The sentences

a strong trendp = 0.055so close (0.05 < p ≤ 0.1)

This was associated with a significantly higher acetylation level of histone H1 (H1) and tumor suppressor p53 protein (p53) as well as a strong trend towards an increase in acetylated forkhead box protein O1 (FoxO1) in Sirt1 ciKO mice ( p = 0.055).

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