The S6k1 −/− mice showed a trend for being hyperactive, but this did not reach significance for either gender (males: F 1,33 = 1.266, P = 0.271; females: F 1,31 = 3.265, P = 0.080).
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Genetic deletion of S6k1 does not rescue the phenotypic deficits observed in the R6/2 mouse model of Huntington's disease.
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